Investigations by Haileybury pupils advance biomedical research: a first in Europe

Haileybury pupils are the first in Europe using fruit flies to advance biomedical research

It is an exciting time for some of our most creative and ambitious young scientists whose research could contribute to finding cures for human diseases like pancreatic cancer and diabetes.

We are proud to be the only school in Europe offering Stan-X – an open-ended science programme based on experimental biology, allowing pupils to build resilience in learning with trial and error. The ultimate goal of the research is to introduce students and their teachers to genuine, unscripted experimental science.

Working collaboratively with Stanford University in the US and the University of Oxford, Stan-X is comparable to a graduate genetics course and is part of an innovative study involving other schools and colleges around the world.

“We are very proud to have been invited to be involved in this project and to be the only school in Europe offering Stan-X. It is very exciting indeed to be involved in a project that so significantly enhances our pupils’ scientific understanding.

We are hopeful that our new Science Centre will be completed in two years’ time. It is an ambitious project and ground-breaking, in that integral to the project, it will be a standalone facility for scientific and technological research.

Stan-X is the first of many advanced research projects that will be undertaken at Haileybury by our pupils over the course of the coming years.” The Master, Martin Collier, said.

The Stan-X programme currently involves seven Lower Sixth pupils who are working with teaching staff to create a laboratory from scratch. Once up and running, ‘team taught’ sessions will see pupils use modern stereo-microscopes to identify phenotypic markers in the fruit fly Drosophila melanogaster, such as curly wings, stubble hair or white eyes.

Fruit flies are considered a model organism and a century of research has shown that humans and fruit flies share many mechanisms that are crucial for development, growth, function and survival. The aim of the research is to use fruit flies genetics to investigate cellular and molecular mechanisms that underlie human diseases. Results obtained at Haileybury will provide new tools and insights to a global community of researchers investigating diseases like diabetes and cancer.

It is the brainchild of Stanford Professor Seung Kim, of Stanford University, who wanted to provide opportunities for secondary school teachers and students to perform experiments without a known outcome, rather than predictable lab exercises carried out in science classes across the globe. The course originated at Phillips Exeter Academy, New Hampshire, nine years ago and we are offering it as an academic enrichment option with seven sessions a week.

Professor Seung Kim said:

“The essence of science is discovery. But too often science is taught in a very general way. That’s why my colleagues and I developed a programme to allow them to do genuine experiments and make discoveries in school.

“The Haileybury pupils will play an important role in this research but, perhaps most importantly, will experience the joy, mystery and anxiety of attempting to make a discovery at an earlier stage of their education than most school pupils. We think that for some, perhaps many, this experiment could be transformative.

“Very few school pupils get the chance to be involved in the planning, execution and interpretation of scientific experiments to which teachers and students don’t already know the answers – I am sure that the Haileybury team will find this work exhilarating. Our additional expectation is that the instructors will quickly achieve considerable autonomy, insuring the durability and flexibility of this experimental science programme.”

Pupils work at fly stations, using a fly pad (which exposes the flies to carbon dioxide and puts them temporarily to sleep) and a very fine paintbrush to sort and organise flies observed with a stereomicroscope. A glow-in-the-dark protein helps establish where an injected chunk of DNA has ‘landed’.

The process involves a series of ‘crosses’ which act as checkpoints throughout the breeding programme, and which generate new fly strains of great value to the community of science. Pupils and teachers will collaborate and experience the highs and lows of the science experiment, allowing them to see science in its purest form. Findings and flies are sent to Stanford research associate Lutz Kockel, and other Stan-X partner schools who verify the results, then submit the new fly strains to an international stocking centre which distributes strains to individual investigators, on request.

In prior Stan-X partnerships, research findings co-authored by pupils and instructors have been published in peer-reviewed science journals, and presented at international meetings. Similar outcomes are anticipated for the Stan-X partnership with Haileybury.

There are also plans to establish an award for a Haileybury Stan-X Scholar to work over the summer months at the University of Oxford, or in the Kim laboratory in Stanford.

Stan-X Presentation Accepted at the 2021 New Jersey Science Convention

Nicole Lantz, and Dr. Elizabeth Fox (Lawrenceville School), and Seung Kim have been invited to present their work on Stan-X as part of a virtual professional development series this year at the New Jersey Science Convention. This presentation is scheduled for February 7, 2021 11:30-12:30 PM EST. 

This presentation is one of a series targeting multiple grade levels and science areas. Each session will include a host and moderator. Live sessions will be recorded and archived for future viewing by registered attendees. Attendee registration for sessions will be handled by the NJSC staff. Please return to our News column in the future for further information and links.

Stan-X Moving Forward Despite the Pandemic

After the successful conclusion of training sessions in the Discover Now teaching academy this July, 2020, multiple schools have started Stan-X programs this fall. As part of our commitment to engaging with partnering teachers and their classes, Dr. Kim has visited with classes (by invitation) at multiple times this past month. Some highlights :

• Dalton School, NYC, NY: Seung Kim was hosted by Dr. Jessica Joiner on Wednesday November 18, 2020. Dr. Kim joined a group of over 20 students, faculty and Dalton School leaders to present the motivation, rationale and plans for the fruit fly-based Stan-X course developing at Dalton this fall and winter quarter. There was a lively discussion and Q&A period! Plans are afoot to visit the class next quarter to discuss experimental progress and primary literature related to the course.

• Haileybury School, United Kingdom: Seung visited the classroom of Victoria Turner and Gareth Lewis, who hosted a teleconference on Friday September 11th. Dr. Kim joined participating Stan-X students and instructors in class to discuss an overview of the experimental work planned this year.

Dr. Kim returned to lead a class discussion on Friday November 27th via videoconference. He joined the current group of 7 lower Sixth formers at Haileybury for over an hour to discuss the original journal article, “Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes” by Rulifson et al. (2002). For all the students, this was the first time they had a chance to read and discuss primary article from a scientific journal. In this case, the discussion was led by a senior author on the study! Reading and understanding primary articles in science journals is a basic skill of practicing scientists. Students have had this experience at other Stan-X partner schools, and based on the enthusiastic responses of the Haileyburians, we are planning to repeat this in the coming term.

• Lawrenceville School: Nicole Lantz and Elizabeth Fox, partnering instructors at the Lawrenceville School Research Molecular Genetics (RMG) class, have built an innovative system for remote, real-time interactions at their fly stations – comprised of a dissecting stereomicroscope, and fly ‘pad’ with CO2 on the microscope stage. One student in class positions flies onto the fly pad, and uses a phone camera mounted onto their microscope to transmit images of flies on the stage to partnering students physically distanced, e.g. in their home or dorm room. This allows two or more students to view and score fly phenotypes simultaneously, whether they are in the actual classroom or viewing via teleconferencing. Students from multiple Stan-X partner schools, including Commack High School in Long Island, NY and Haileybury School in the U.K. participated in these sessions. At multiple times throughout mid-November, Dr. Kim also joined via this scheme to interact with students at their microscopes, and discuss fly husbandry and phenotypes. The audio allowed Kim and the students to discuss findings in class. This terrific adaptation to the need for distanced learning has helped move research work forward in the RMG class, even in the time of COVID-19.

In November 2020, the students from Haileybury and Lawrenceville met online to discuss their flywork. Lawrenceville students used Zoom to show the Haileybury students their flies under the microscope, allowing the two groups of students to discuss their common research while it was actively happening.